Table 3.

ADME prediction data obtained from SwissADME online tool (GI = Gastro intestinal, BBB = Blood Brain Barrier, Pgp = P glycoprotein, CYP = Cytochrome, log Kp = skin permeation).

Compounds	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	log Kp (cm/s)
1	High	N	N	N	N	N	N	N	−7.39
2	High	Y	N	N	N	N	N	N	−6.34
3	High	N	Y	Y	N	N	N	N	−7.5
4	High	Y	Y	Y	N	N	N	N	−6.55
5	High	Y	Y	Y	N	N	N	N	−6.55
6	High	Y	Y	Y	N	N	Y	N	−6.5
7	High	Y	Y	Y	N	N	Y	N	−6.27