Table 5.
Toxicity prediction of selected compounds as Data obtained from pkCSM server.
| Compounds | AMES toxicity | Max. tolerated dose (Human) | hERG I inhibitor | hERG II inhibitor | Oral Rat Acute Toxicity (LD50) | Oral Rat Chronic Toxicity (LOAEL) | Skin sensitization | Minnow toxicity |
|---|---|---|---|---|---|---|---|---|
| 1 | No | 0.55 | No | No | 2.196 | 0.877 | No | 3.241 |
| 2 | No | 0.881 | No | No | 2.516 | 2.333 | No | 1.666 |
| 3 | No | 0.354 | No | No | 2.521 | 0.802 | No | 2.364 |
| 4 | Yes | 0.018 | No | No | 2.564 | 1.381 | No | 2.255 |
| 5 | Yes | 0.019 | No | No | 2.553 | 1.39 | No | 2.005 |
| 6 | No | −0.03 | No | No | 2.645 | 1.302 | No | 1.776 |
| 7 | No | −0.018 | No | No | 2.641 | 1.313 | No | 1.922 |