Table 3.

Risk of all cause mortality in offspring according to timing and severity of maternal pre-eclampsia*

Variables for pre-eclampsia	No of deaths	Follow-up (person years)	Rate (per 100 000 person years)	Crude hazard ratio (95% CI)	Adjusted hazard ratio† (95% CI)
						No HDP	19 119	45 534 378.72	41.99	1.0 (reference)	1.0 (Reference)
Timing:
Late onset	338	913 226.04	37.01	0.90 (0.81 to 1.01)	0.80 (0.72 to 0.89)
Early onset	394	327 980.19	120.13	2.63 (2.38 to 2.90)	2.71 (2.45 to 3.00)
Severity:
Moderate	423	1 013 731.05	41.73	1.00 (0.91 to 1.10)	0.90 (0.82 to 0.99)
Severe and HELLP syndrome	309	227 475.18	135.84	3.10 (2.77 to 3.47)	3.10 (2.77 to 3.47)
Timing and severity interaction:
Late onset:
Moderate	287	786 320.06	36.50	0.90 (0.80 to 1.01)	0.78 (0.70 to 0.88)
Severe and HELLP syndrome	51	126 905.99	40.19	0.92 (0.70 to 1.22)	0.90 (0.68 to 1.18)
Early onset:
Moderate	136	227 410.99	59.80	1.29 (1.09 to 1.53)	1.33 (1.12 to 1.57)
Severe and HELLP syndrome	258	100 569.19	256.54	5.79 (5.12 to 6.54)	6.06 (5.35 to 6.86)

CI=confidence interval; HDP=hypertensive disorder of pregnancy; HELLP=haemolysis, elevated liver enzymes, and low platelets.

^*Includes moderate pre-eclampsia, severe pre-eclampsia, and HELLP syndrome.

^†Offspring age as time scale, adjusted for calendar year; sex; singleton; parity; birth year of child; maternal age, smoking, cohabitation, country of origin, residence, education, income at birth, pre-pregnancy body mass index, and history of diabetes; and parental history of cardiovascular disease before birth of the child.