Table 3.

Adverse events.

Adverse events	Microparticles group (n = 40)				Placebo group (n = 39)
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
Pyrexia	7 (18%)	2 (5%)	1 (3%)	0	5 (13%)	2(5%)	0	0
Vomiting	4 (10%)	0	1 (3%)	0	4 (10%)	1 (3%)	0	0
Fatigue	4 (10%)	0	0	0	3 (8%)	1(3%)	1 (3%)	0
Nausea	3 (8%)	1 (3%)	0	0	5 (13%)	3 (8%)	1 (3%)	0
Thoracalgia	2 (5%)	1 (3%)	0	0	0	0	0	0
Chest stuffiness	0	0	0	0	4 (10%)	1 (3%)	0	0
Leukopenia	3 (8%)	1 (3%)	0	0	5 (13%)	3 (8%)	1 (3%)	0
Infection	0	1 (3%)	0	0	0	1 (3%)	2 (5%)	0
Thrombus	0	0	0	0	0	1 (3%)	0	0
Atrial Fibrillation	0	0	0	0	0	1 (3%)	0	0
Pain	0	2 (5%)	0	0	0	2 (5%)	0	0
Hypertension	0	1(3%)	0	0	0	1 (3%)	1 (3%)	0
Anemia	3 (8%)	2 (5%)	0	0	2 (5%)	1 (3%)	0	0
Abnormal liver function	1 (3%)	4 (10%)	1 (3%)	0	4 (10%)	0	0	0
Constipation	1 (3%)	1 (3%)	0	0	2 (5%)	0	0	0
Hypoproteinemia	3 (8%)	1 (3%)	0	0	2 (5%)	1 (3%)	0	0
Cough	1 (3%)	0	0	0	0	1 (3%)	1 (3%)	0
Dyspnoea	0	0	0	0	0	0	1 (3%)	0
Urine leukocytosis	0	1 (3%)	0	0	0	0	0	0
Erythra	1 (3%)	1 (3%)	0	0	0	1 (3%)	0	0