Table 3.

Multivariable predictors of significant coronary artery disease

		Model 1	Model 2	Model 3
ORs for significant predictors	Diabetes mellitus	2.94 (1.33–6.49)	3.98 (1.67–9.50)	3.44 (1.48–8.01)
	Hypercholesterolaemia	2.40 (1.20–4.78)	2.57 (1.23–5.37)	2.71 (1.32–5.59)
	Ischaemia	97.49 (37.10–218.91)	53.91 (21.80–133.30)	61.00 (24.80–149.70)
	Peak LVEF	—	0.93 (0.90–0.96)	—
	Peak GLS	—	—	1.15 (1.07–1.24)
Model statistics	P-value	<0.01	<0.01	<0.01
	C-statistic	0.78 (0.69–0.87)	0.83 (0.74–0.91)	0.84 (0.75–0.92)
	Sensitivity	61%	73%	76%
	Specificity	95%	94%	94%
	PPV	72%	72%	72%
	NPV	92%	94%	95%
	AIC	227	207	215

Odds ratios for quantitative predictors are shown for a unit increase. OR, odds ratio; PPV, positive predictive value; NPV, negative predictive value; AIC, Akaike information criterion; —indicated not applicable. C-statistic confidence intervals reflect the distribution of values from 2.5th to 97.5th percentiles from the bootstrapping analysis.