Extended Data Fig. 2. Estimates of the selection coefficients for the four SNPs of interest and power of the inference procedure.

(A) Distributions of ${\hat{s}}_{\mathrm{MLE}}$ for the four SNPs when replicates are simulated with the corresponding bootstrapped allele frequency distributions as initial conditions and bootstrap-corrected estimates ${\tilde{s}}_{\mathrm{MLE}}$. Whiskers on the violin plots label the 2.5-, 50-, and 97.5-percentiles of their respective distributions. (B) ROC and (C) Precision-Recall curves for the estimation procedure to distinguish replicates under selection from those under neutrality.