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. 2022 Oct 5;16:886524. doi: 10.3389/fnbeh.2022.886524

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Copyright © 2022 Schoenrock, Gagnon, Olson, Leonardo, Philip, He, Reinholdt, Sukoff Rizzo, Jentsch, Chesler and Tarantino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different patterns of sensitized cocaine locomotor behavior in CC strains of interest. Cocaine exposures 1–5 correspond to Days 3–11 in the sensitization protocol. (A) CC001/UncJ and CC026/GeniUncJ show similar rates of sensitization but differ in overall locomotor response; (B) CC059/TauUncJ mice exhibit a robust sensitization response across the first four exposures while CC028/GeniUncJ mice don’t begin to show a sensitized response until the third exposure and (C) the maximal locomotor response in CC018/UncJ mice is reached by the second dose whereas CC027/GeniUncJ mice show the highest response after a single exposure and locomotor activity does not increase upon additional exposures.