Table 1.

Summary of literature analyzing MMP expression in endometriosis.

References	Important MMP/TIMP subtype(s) identified	Location of endometriosis	Main finding(s)/conclusion(s)
Sillem et al. (39)	TIMP-2	Unspecified	Increased TIMP-2 transcription may increase endometrial cell invasiveness
Mizumoto et al. (29)	MMP-1,−2,−7, -9 TIMP-1	Endometrioma	MMP primarily produced from stromal cells which may cause ECM destruction
Sillem et al. (31)	MMP-1,−2, -3 TIMP-1,−2	Unspecified	IL-1 induces significantly greater MMP-3 secretion from eutopic EM tissue not observed in controls
Chung et al. (35)	MMP-2 TIMP-2	Unspecified	Increased eutopic endometrial MMP-2 expression in EM and significantly lower TIMP-2
Uzan et al. (33)	MMP-2,−3, -11 TIMP-1,−2	Colorectal, endometrioma, peritoneal	MMP profile depends on EM location; Highest MMP-2,−3, and−11 expression in colorectal EM; TIMP-2 expression higher in peritoneal EM
Hudelist et al. (40)	MMP-1	Endometrioma, peritoneal	Significantly increased MMP-immunohistochemistry staining in ectopic lesions; non-significant differences in eutopic MMP-1 compared to controls
Kyama et al. (11)	MMP-3	Unspecified	Significantly higher eutopic MMP-3 mRNA expression in EM
Matsuzaki et al. (41)	MMP-9	Unspecified	Higher eutopic MMP-9 in EM; PFK 115-584 inhibited activity and reduced invasive cells
Cominelli et al. (32)	MMP-27	Endometrioma, peritoneal, rectovaginal	Increased macrophage MMP-27 in endometrioma and peritoneal EM, but not in rectovaginal lesions
Tang et al. (38)	MMP-2, -9 TIMP-1,−2, -3	Unspecified	Decreased MMP-2 DNA methylation in EM cells; Significantly higher MMP-2,−9 and TIMP-1,−2 transcription abundance in EM; Significantly lower TIMP-3 transcription abundance in EM