Figure 4.

Obesity-induced oxidative stress and male infertility. Obesity-induced oxidative occurs because of (i) increase in metabolic reaction due to elevated glucose and lipids levels, (ii) increase in the level of stress hormones and proteins and (iii) alteration in genetic composition. The occurrence of oxidative stress leads to disrupted hypothalamo-pituitary gonadal axis, induction of apoptosis, increased sperm DNA fragmentation and alters cell cycle, which cumulatively result in male infertility.