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. 2021 Dec 7;3:714829. doi: 10.3389/frph.2021.714829

Table 3.

Summary of organisms that were observed to have significantly increased relative abundances (%RA) between phase 3 study groups.

Group comparison Study day
2 3 5 7 9
N9 v HEC >Actinomyces >Haemophilus
>Helcococcus
BZK v HEC >Acidovorax
>Corynebacterium
>Corynebacterium
>Helcococcus
>Rhodococcus
>Cloacibacterium >Corynebacterium >Helcococcus >Rhodococcus
N9 v Sham >Helcococcus
BZK v Sham >Helcococcus
Sham v N9 >E. coli
HEC v N9 >E. coli
N9 v BZK >Haemophilus >Haemophilus
BZK v N9 >Cloacibacterium >Corynebacterium >Rhodococcus

Following the assignment of CTs to eubiotic or dysbiotic (inflammatory) state, we established specific changes in specific microbiota that were significant by both Wilcoxon and two test methods (p <0.05) for each comparison by phase 3 study day. The indicated polymerase chain reaction (PCR) targets were each significantly higher in average relative abundance in the indicated groups relative to the comparator group.