Table 3.
Summary of organisms that were observed to have significantly increased relative abundances (%RA) between phase 3 study groups.
Group comparison | Study day | ||||
---|---|---|---|---|---|
2 | 3 | 5 | 7 | 9 | |
N9 v HEC | >Actinomyces |
>Haemophilus >Helcococcus |
|||
BZK v HEC |
>Acidovorax >Corynebacterium |
>Corynebacterium >Helcococcus >Rhodococcus |
>Cloacibacterium >Corynebacterium >Helcococcus >Rhodococcus | ||
N9 v Sham | >Helcococcus | ||||
BZK v Sham | >Helcococcus | ||||
Sham v N9 | >E. coli | ||||
HEC v N9 | >E. coli | ||||
N9 v BZK | >Haemophilus | >Haemophilus | |||
BZK v N9 | >Cloacibacterium >Corynebacterium >Rhodococcus |
Following the assignment of CTs to eubiotic or dysbiotic (inflammatory) state, we established specific changes in specific microbiota that were significant by both Wilcoxon and two test methods (p <0.05) for each comparison by phase 3 study day. The indicated polymerase chain reaction (PCR) targets were each significantly higher in average relative abundance in the indicated groups relative to the comparator group.