Figure 3.

Ovarian reserve in mice after irinotecan treatment. Mature female mice were treated as described in the legend of Figure 1. Ovaries were excised from mice 1 week (white bars) or 3 months (gray bars) after treatment and ovarian SOHLH2 (A), NOBOX (B) and FIGLA (C) mRNAs were measured. Bars are % of control ± standard error of mean. (*), significantly different from saline value (P <0.05). CPT-11, irinotecan; CTX, cyclophosphamide.