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. 2022 Mar 14;4:812053. doi: 10.3389/frph.2022.812053

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Copyright © 2022 Levi, Ben-Aharon and Shalgi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irinotecan-mild testicular toxicity. Mature male mice (2 months old) were weighted, injected intraperitoneally with saline, irinotecan (100 mg/kg; CPT-11) or cyclophosphamide (100 mg/kg; CTX). Mice were sacrificed 1 week (4, 5, and 5 mice, respectively; white bars) or 3 months (4, 5 and 5 mice, respectively; gray bars) later. Testis weight (A) and epididymis weight (B), epididymal sperm count (C), sperm motility (D) and serum AMH (E) were measured. Bars are mean ± standard error of mean. (*), significantly different from saline value (P <0.05).