TABLE 2.
Description of the criteria used for the investigation of the discoveries listed in Supplementary Table S2 (see Supplementary Material).
| Criteria | Details |
|---|---|
| Discoveries | Natural product-related discoveries mentioned in the respective publication are expressed as hypothetical relationships between two or more concepts |
| Natural product relevant concept | All natural product-related concepts mentioned in the respective discovery are listed individually |
| Identity of the concept | The identity of the natural product-related concept is elucidated and the concept is classified into semantic categories. Substances were classified into compound classes |
| Natural product category | Concepts are assigned to the same natural product categories used in Supplementary Table S1 (Supplementary Material). The categories are listed in Table 1 |
| Natural source | The source of the natural product is indicated by using one of the following categories: plant, animal, fungus, microorganism, and mineral |
| Taxonomic information about the source | The taxonomic identity of the natural source is elucidated using the resources listed below. Priority is given to the source from which the natural product originally was discovered. If appropriate, additional important natural sources are listed. The taxonomic information stated in the resources was verified using Kew’s Medicinal Plant Names Services (MPNS, 2020, Medicinal Plant Names Services) or Plants of the World online (Plants of the World Online, 2020) for plants, and Global Biodiversity Information Facility (GBIF) (GBIF, 2020) for all other organisms. For plants, information about the relevant plant part (if available), as well as the family, is indicated, e.g. Taxus brevifolia Nutt. (bark), [Taxaceae] |
In addition to the resources listed in Table 1, the following literature was used for the elucidation of the natural source: HagerROM, 2009, Hagers Enzyklopädie der Arzneistoffe und Drogen (Blaschek et al., 2009); Vardanian’s and Hruby’s Synthesis of Best-Seller Drugs (Vardanian and Hruby, 2016); Dictionary of Antibiotics and Related Substances (Bycroft and Payne, 2013).