Summary of findings 5. Summary of findings: misoprostol 400 µg + diclofenac.
| Misoprostol 400 µg + diclofenac compared with diclofenac for pain with IUC insertion | ||||
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Patient or population: women with IUC being inserted Settings: clinic Intervention: misoprostol 400 µg (sublingual) + diclofenac 100 mg Comparison: diclofenac 100 mg | ||||
| Outcomes | Relative effect (95% CI) | No. of participants (studies) | Quality of evidencea (GRADE) | Notes on parity |
| Side effect: headache | OR 5.68 (1.23 to 26.19) | 255 (Ibrahim 2013) |
⊕⊕⊕⊝ moderate | Prior cesarean only |
| Side effect: abdominal pain | OR 3.93 (1.41 to 10.97) | 230 (Ibrahim 2013) |
⊕⊕⊕⊝ moderate | Prior cesarean only |
| Side effect: shivering | OR 5.48 (1.41 to 21.33) | 79 (Sääv 2007) |
⊕⊕⊕⊝ moderate | Nulliparous |
| Satisfaction: would choose treatment again | OR 0.30 (0.14 to 0.65) | 255 (Ibrahim 2013) |
⊕⊕⊕⊝ moderate | Prior cesarean only |
| Satisfaction: would recommend treatment to friend | OR 0.36 (0.16 to 0.81) | 255 (Ibrahim 2013) |
⊕⊕⊕⊝ moderate | Prior cesarean only |
| IUC: intrauterine contraception: CI: Confidence interval; OR: Odds Ratio | ||||
| GRADE Working Group grades of evidence Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. | ||||
aWhen the evidence came from only one trial, we downgraded one level; further research may change the estimate.