3. Outcome summary: side effects and satisfaction.

Study	N	Experimental intervention	Delivery	Side effects or adverse events	Satisfaction or acceptability
NSAID
Karabayirli 2012	103	Naproxen 550 mg	Tablet	0	Unsatisfied: naproxen < placebo
Hubacher 2006	2019	Ibuprofen 400 mg	Tablet, oral	_	_
Jensen 1998	55	Ibuprofen 600 mg	Tablet, oral	_	_
Bednarek 2015	202	Ibuprofen 800 mg	Tablet, oral	_	_
Chor 2012	87	Ibuprofen 800 mg	Tablet, oral	0	_
Massey 1974	58	Naproxen 300 mg (x 4 doses) + paracervical block (1% lidocaine 8 mL)	Tablet, oral	NAa	_
Ngo 2014	67	Ketorolac 30 mg	Intramuscular injection	NA	NA
Lidocaine
Maguire 2012	200	2% gel (1 mL)	Swab	NA	NA
Mohammad‐Alizadeh‐C 2010	96	2% gel	Swab	_	_
Allen 2013	150	2% gel (6 mL)	2 sites, 3 mL each	NSc	NS
Nelson 2013	40	2% (1.2 mL)	Infused, 3 sites	_	_
McNicholas 2012	200	2% gel (2.5 to 4 mL)	0.5 to 1 mL Topical; 2 to 3 mL inserted	NA	_
Rapkin 2014	64	2% gel (5 mL)	Self‐inserted vaginally	_	NA
Tornblom‐Paulander 2015	218	4% gel (8.5 mL)	Topical, 3 sites	NS	_
Aksoy 2015	200	10% spray (40 mg)	Topical, 2 sites; 4 puffs total	NA	_
Ahmadi Doulabi 2013	92	EMLA cream 5% (lidocaine + prilocaine) (5 g)	Swab	_	_
Mody 2012	50	1% paracervical block (10 mL)	2 sites, 5 mL each	NS	_
Cırık 2013b	95	1% paracervical block (10 mL)	2 sites, 5 mL each	NS	_
Castro 2014	100	2% intracervical block (1.8 mL)	4 sites	_	NS
Misoprostol
Sääv 2007	80	400 μg + diclofenac	Sublingual	Shivering: misoprostol > placebo; Other: NS	NS
Ibrahim 2013	274	400 µg + diclofenac	sublingual	Headache or abdominal pain: misoprostol > placebo; Other: NS	Choose again or recommend to friend: misoprostol < control
Heikinheimo 2010	89	400 µg	Sublingual	NS	_
Edelman 2011	40	400 µg	Buccal	NS	_
Lathrop 2013	73	400 µg	Buccal	_	NS
Espey 2014	83	400 µg	Buccal	NS	NS
Lotke 2013	61	400 μg	Vaginal or buccal	NS	NS
Swenson 2012	108	400 μg	Vaginal or buccal	NA	NS
Dijkhuizen 2011	270	400 μg	Vaginal	NS	_
Scavuzzi 2013	190	400 μg	Vaginal	NS	Misoprostol > placebo
Other
Bednarek 2013	24	Nitroprusside gel 1%	1 mL	NS	Satisfaction with pain control: NS; Satisfaction with procedure: nitroprusside < placebo
Micks 2014	24	Nitroglycerin ointment 0.5 mg	1 mL	NS	Satisfaction with pain control or procedure: NS
Karabayirli 2012	103	Tramadol 50 mg	Tablet	None	NS
Shahnazi 2012	106	Lavender 10 drops in diluted milk	3 drops on cotton, inhaled	None	_
Cameron 2013	200	Delayed bladder emptying (after IUC insertion)	Oral (water 1 L)	_	_

^aNA = not available (assessed but not reported, or provided insufficient data)
 ^bExcluded from sensitivity analysis due to low quality evidence
 ^cNS = no significant difference between study arms