Comparison 17. Misoprostol 400 µg + diclofenac 100 mg versus diclofenac 100 mg alone.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Median pain score at IUD insertion			Other data	No numeric data
2 Side effects or adverse events	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Headache	1	255	Odds Ratio (M‐H, Random, 95% CI)	5.68 [1.23, 26.19]
2.2 Abdominal pain	1	230	Odds Ratio (M‐H, Random, 95% CI)	3.93 [1.41, 10.97]
2.3 Nausea	2	309	Odds Ratio (M‐H, Random, 95% CI)	1.98 [0.29, 13.40]
2.4 Any side effect	1	79	Odds Ratio (M‐H, Random, 95% CI)	1.76 [0.72, 4.29]
2.5 Shivering	1	79	Odds Ratio (M‐H, Random, 95% CI)	5.48 [1.41, 21.33]
2.6 Diarrhea	1	79	Odds Ratio (M‐H, Random, 95% CI)	2.52 [0.84, 7.59]
2.7 Vomiting	1	79	Odds Ratio (M‐H, Random, 95% CI)	2.11 [0.18, 24.24]
3 Satisfaction or acceptability	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Overall very satisfied or satisfied	1	255	Odds Ratio (M‐H, Random, 95% CI)	0.25 [0.05, 1.19]
3.2 Would choose treatment again	1	255	Odds Ratio (M‐H, Random, 95% CI)	0.30 [0.14, 0.65]
3.3 Would recommend treatment to a friend	1	255	Odds Ratio (M‐H, Random, 95% CI)	0.36 [0.16, 0.81]
3.4 Rated insertion experience as 'very little unpleasant'	1	79	Odds Ratio (M‐H, Random, 95% CI)	0.46 [0.13, 1.66]