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. 2021 Aug 19;1:709533. doi: 10.3389/fbinf.2021.709533

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Copyright © 2021 Moody, Wilson, Boer, Holien, Flanagan, Jaworowski and Plebanski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Research pipeline of the project to explore the potential of immune cross-reactivity. Protein sequences for select SARS-CoV-2 proteins were obtained for epitope predictions (highlighted green. Spike: Surface glycoprotein. E, envelope; M, membrane; NP, nucleoprotein). Using the Immune Epitope Database (IEDB) epitope prediction tool, B cell epitopes were predicted and those selected were screened against human proteins using the NCBI Blastp tool. Human proteins with sequence similarities to the SARS-CoV-2 epitopes were investigated for their function, disease association and alignment localization. Potential immune cross-reactivity between SARS-CoV-2 and human alignments was then explored by applying specific selection criteria. Alignments of interest from the human proteins were explored as potential epitopes within the human protein sequences.