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. 2021 Aug 19;1:709533. doi: 10.3389/fbinf.2021.709533

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Copyright © 2021 Moody, Wilson, Boer, Holien, Flanagan, Jaworowski and Plebanski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Workflow to identify human proteins that share sequence similarities with SARS-CoV-2 immunogenic regions. The predicted SARS-CoV-2 B cell epitopes were compared to the human proteome using the NCBI protein BLAST tool. Two epitopes, NP1-51 and NP164-216 had no sequence similarities to human proteins. The top 100 sequence alignments from the remaining 23 epitopes were narrowed by removing duplicates (alternative nomenclature/sequence IDs), uncharacterized/hypothetical proteins and the variable regions of lymphocyte receptors. This resulted in a final list of 281 sequence alignments that was comprised of 256 human proteins.