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. 2021 Jun 8;1:667012. doi: 10.3389/fbinf.2021.667012

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Copyright © 2021 Krishnan and Krishnan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network of glycans along with the enzymes involved in generating the 10 most abundant glycans as per Zhang et al. [panel (A)]. All the 10 glycans (identified by nodes 1, 4, 9, 11, 16, 20, 24, 29, 33, and 39) were traced back to their Man-9 parent glycan (node 102), and the biosynthesis pathway involved the use of nine enzymes as presented in the key to the right, as denoted by the colors. Panels (B) and (C) display disruption of the network of biosynthesis pathways when using the alpha-mannosidase (Man-II) blocking agent deoxynojirimycin or swainsonine [panel (B)] and when using the alpha-1,6-fucosyltransferase (FucT8) agonist indolizidine [panel (C)]. In the network generated with enzymes in panels (B) and (C), only three of the total 10 glycans are formed.