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. 2021 Jun 8;1:667012. doi: 10.3389/fbinf.2021.667012

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Copyright © 2021 Krishnan and Krishnan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network of glycans along with the enzymes involved in generating the glycans as per Shajahan et al. [panel (A)]. All the 48 glycans (identified by numbered nodes) were traced back to their Man-9 parent glycan (node 15). The colors (explained in the key) depict the different enzymes involved in the biosynthesis pathway. A total of 12 N-glycan biosynthesis enzymes were required to develop this profile of glycans. Panels (B) and (C) display disruption of the network of glycans generated when using the alpha-mannosidase (Man-II) blocking agent deoxynojirimycin or swainsonine [panel (B)] and when using the alpha-1,6-fucosyltransferase (FucT8) agonist indolizidine [panel (C)]. In the network generated with enzymes in panel (B), only five glycans are formed, and in panel (C), only 21 of the 48 are formed.