TABLE 1.
Glycosylation sites on the SARS-CoV-2 spike (S) protein.
| SARS-CoV-2 glycosites | Glycosylated per cryo-EM a | Glycosylated per MS data b , c , d , e |
|---|---|---|
| N17 | No | Yes b , c , d /no e |
| N61 | Yes | Yes |
| N74 | No | Yes |
| N122 | Yes | Yes |
| N149 | No | Yes |
| N165 | Yes | Yes |
| N234 | Yes | Yes |
| N282 | Yes | Yes |
| N331 | Yes | Yes |
| N343 | Yes | Yes b , c , d /no e |
| N603 | Yes | Yes b , c , d /no e |
| N616 | Yes | Yes |
| N657 | Yes | Yes |
| N709 | Yes | Yes b , c , d /no e |
| N717 | Yes | Yes b , c , d /no e |
| N801 | Yes | Yes |
| N1074 | Yes | Yes |
| N1098 | Yes | Yes |
| N1134 | Yes | Yes |
| N1158 | No | Yes |
| N1173 | No | Yes |
| N1194 | No | Yes |
a
Walls AC et al., Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell, 180: 281–292, 2020.
b
Shajahan A et al., Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2. Glycobiology, 30 (12): 981–988, 2020.
c
Watanabe Y et al., Site-specific glycan analysis of the SARS-CoV-2 spike. Science, 369 (6501): 330–333, 2020.
d
Zhang Y et al., Site-specific N-glycosylation characterization of recombinant SARS-CoV-2 spike proteins. Molecular and Cellular Proteomics, 20: 100,058, 2021.
e
Sanda M et al., N- and O-glycosylation of the SARS-CoV-2 spike protein. Analytical Chemistry, 93 (4): 2003–2009, 2021.