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. 2021 Oct 26;1:723337. doi: 10.3389/fbinf.2021.723337

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Copyright © 2021 Cheon, Kan, Prevedello, Oostindie, Dovedi, Hawkins, Marchingo, Heinzel, Duffy and Hodgkin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the two Cyton models. (A) The original Cyton model (Hawkins et al., 2007) where stochastic times to divide and to die are chosen independently after each cell division. Cells cease their motivation to divide based on division-counting mechanism. (B) The Cyton2 model incorporates significant correlation in division times between siblings, as well as familial inheritance of death and division destiny times. (C) A consequence of the correlation and inheritance is that the resulting family trees are heterogeneous, but highly concordant. By exploiting this property, a family tree can be summarised by substituting the average values of its times and fate at each generation. An example of clonally collapsed family tree and its key variables is shown.