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. 2021 Oct 18;1:724127. doi: 10.3389/fbinf.2021.724127

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Copyright © 2021 Feher, Graus, Coelho, Farrell, Goyette and Gaus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Relationship between SNPCA and D _BNN. D _BNN has a positive trend with r, and this effect is strongest for larger clusters. Trend lines are fitted with robust linear models and are supplied for visualisation purposes. (B) Relationship between SNPCA and cluster count N _clus. N _clus has an angular dependence within the SNPCA. The relationship is strongest for well separated binding sites otherwise individual clusters appear to be larger aggregates. Trend lines are fitted with robust linear models and are supplied for visualisation purposes. (C) Relationship of D _B with SNPCA. After normalising SNPC1 to the smallest value in each cluster, it has a positive trend with D _B. Trend lines are fitted with robust linear models and are supplied for visualisation purposes.