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. 2021 Sep 3;1:731340. doi: 10.3389/fbinf.2021.731340

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Copyright © 2021 Kapitanov, Chabot, Narula, Roy, Neubert, Palandra, Farrokhi, Johnson, Webster and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total IL-13 accumulation after IMA-026 administration in Phase I trial - model simulations vs published data. Different color solid lines correspond to different doses, open circles with corresponding colors are clinical data. Labels: SC, subcutaneous; IV, intravenous; HV, healthy volunteers; MA, mild asthmatics. The model reasonably captures the behavior using internal affinity measures, previously published target data, and published PK parameters for IMA-026, without fitting any parameters.