FIGURE 9.

Projected IL-13 neutralization in lung at two dosing schedules for IMA-026. Two doses of 2 mg/kg a week apart (solid blue line) was the clinically tested dose in asthma patients (NCT00725582). Eight doses of 30 mg/kg a week apart (dashed orange line) is a hypothetical clinical dose at which the projected IMA-026 coverage reaches close to 90% IL-13 neutralization in the lung. Modeling suggests that the mechanism of IL-13 neutralization was likely untested in the clinic due to low tested dose, which is projected to result in low coverage.