TABLE 3.

Isolated nocturnal hypertension in relation to clock genes in multivariate logistic regression

Gene	Chr	SNP	Location	Allele (Minor/Major)	MAF	HWE	Genotype	Odds Ratio (95%CI)	P
CRY1	12	rs4964513	Intron	C/T	0.24	0.32	CC+CT vs TT	1.48 (0.85,2.60)	.17
		rs11613557	Intron	T/C	0.26	0.25	TT+TC vs CC	1.11 (0.64,1.91)	.72
		rs4964518	Intron	T/C	0.27	0.10	TT+TC vs CC	0.93 (0.54,1.61)	.79
CRY2	11	rs7121611	upstream	A/T	0.21	0.18	AA+AT vs TT	1.12 (0.63,1.97)	.70
		rs7945565	Intron	G/A	0.21	0.21	GG+GA vs AA	1.16 (0.65,2.05)	.62
		rs10838524	Intron	G/A	0.21	0.15	GG+GA vs AA	1.07 (0.61,1.89)	.81
BMAL1	11	rs6486121	Intron	T/C	0.17	0.82	TT+TC vs CC	0.76 (0.42,1.38)	.37
		rs3789327	Intron	G/A	0.27	0.71	GG+GA vs AA	1.04 (0.60,1.78)	.89
		rs969485	Intron	A/G	0.43	1.00	AA+AG vs GG	1.21 (0.67,2.19)	.53
		rs3816358	Intron	A/C	0.15	0.98	AA+AC vs CC	1.03 (0.57,1.87)	.92
		rs12363415	Intron	G/A	0.14	0.06	GG+GA vs AA	0.88 (0.47,1.63)	.68
		rs4757144	Intron	A/G	0.44	0.98	AA+AG vs GG	0.77 (0.43,1.38)	.38
CLOCK	4	rs6811520	Intron	T/C	0.26	0.35	TT+TC vs CC	1.17 (0.67,2.05)	.58
		rs13124436	Intron	G/A	0.33	0.96	GG+GA vs AA	1.46 (0.82,2.60)	.20
		rs4580704	Intron	G/C	0.28	0.28	GG+GC vs CC	1.13 (0.64,1.98)	.67
		rs11932595	Intron	G/A	0.08	0.34	GG+GA vs AA	1.36 (0.64,2.88)	.42
		rs1801260	Intron	G/A	0.08	0.39	GG+GA vs AA	1.33 (0.61,2.89)	.47
DEC2	12	rs2291140	Intron	C/T	0.33	0.43	CC+CT vs TT	1.06 (0.61,1.85)	.84
NOC	4	rs9684900	Intron	A/G	0.28	0.04	AA+AG vs GG	1.18 (0.65,2.15)	.59
		rs17050679	Intron	C/G	0.43	0.09	CC+CG vs GG	1.56 (0.85,2.86)	.15
		rs1112828	Intron	G/T	0.43	0.78	GG+GT vs TT	0.75 (0.42,1.33)	.32
NPAS2	2	rs3888170	Intron	A/G	0.43	0.02	AA+AG vs GG	0.66 (0.36,1.19)	.16
PER2	2	rs934945	Exon	T/C	0.30	0.56	TT+TC vs CC	1.47 (0.83,2.59)	.19
		rs6431590	Intron	G/A	0.29	0.66	GG+GA vs AA	0.99 (0.57,1.72)	.97
RORA	15	rs10519096	Intron	A/G	0.09	0.88	AA+AG vs GG	1.37 (0.67,2.78)	.39
		rs16943453	Intron	G/T	0.21	0.41	GG+GT vs TT	0.81 (0.48,1.38)	.46
RORB	9	rs1410225	Downstream	A/G	0.43	0.15	AA+AG vs GG	0.81 (0.45,1.45)	.47
STK38L	12	rs16931815	Intron	G/A	0.42	0.57	GG+GA vs AA	1.31 (0.73,2.34)	.37
TNFRSF9	1	rs2453021	Intron	T/C	0.28	0.16	TT+TC vs CC	0.62 (0.34,1.12)	.11

The logistic regression analyses were adjusted for age, sex, body mass index, diabetes mellitus, current smoking and alcohol intake, nighttime heart rate, sleep duration, sleep after 23:00, seasons, average daily temperature, relative humidity, wind speed, and atmosphere pressure in a dominant model.

Abbreviations: Chr, chromosome; SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy‐Weinberg equilibrium.