Table 6.

Protocols for the paired-pulse TMS paradigms used in individuals with spinal cord injury.

TMS measure	Reference	Muscle	Conditioning pulse intensity	Test pulse intensity	Inter-stimulus interval (ms)	Changes after spinal cord injury
SICI	Mi et al., 2015 (48)	Flexor Carpi Radialis (active 15%–20% MVC)	60% AMT to 110% AMT	MEPhalfmax [defined as the MSO required to elicit a rectified area equal to half of the maximum]	3	Decreased inhibition when AMT not matched; no differences in inhibition when matched for AMT
SICI	Saturno et al., 2008 (84)	Extensor Digitorum Communis	80% RMT	120% RMT	2, 3, 5	Absence of inhibition; no control group
SICI	Roy et al., 2011 (83)	Tibialis Anterior (active 15%–20% MVC)	60% AMT to 110% AMT	½ * MEPmax [The TS intensity was set to the sensitive portion of the recruitment curve (i.e., producing test MEPs near ½ MEPmax).]	3	Inhibition in SCI group seen only at CS of 80% AMT v/s inhibition seen at 60%–90% AMT in healthy controls
LICI	Mi et al., 2015 (48)	Flexor Carpi Radialis (active 15%–20% MVC)	90% AMT to 130% AMT	MEPhalfmax [defined as the MSO required to elicit a rectified area equal to half of the maximum]	150	Decreased in individuals with SCI with and without AMT matching
ICF	Saturno et al., 2008 (84)	Extensor Digitorum Communis	80% RMT	120% RMT	10, 15	Facilitation seen; no control group

AMT, active motor threshold; ICF, intracortical facilitation; SICI, short-interval intracortical inhibition; LICI, long-interval intracortical inhibition; MEP, motor evoked potential; MSO, maximum stimulator output; ms, milliseconds; MVC, maximum voluntary contraction; RMT, resting motor threshold; TMS, transcranial magnetic stimulation; TS, test stimulus.