Table 3.
Univariate and multivariate regression analysis of RFR/FFR discordance predictors.
| Characteristic | UnivariateOR (95% CI) | P-value | MultivariateOR (95% CI) | P-value |
|---|---|---|---|---|
| Age (+ year) | 1.06 (1.01, 1.10) | 0.009 | 1.05 (1.01, 1.10)# | 0.023 |
| Male sex | 0.52 (0.24, 1.14) | 0.10 | 0.68 (0.30, 1.55)## | 0.400 |
| BMI (+1 kg/m2) | 0.95 (0.86, 1.03) | 0.20 | — | — |
| Diabetes | 1.36 (0.67, 2.75) | 0.40 | — | — |
| Smoking | 0.19 | — | — | |
| Never | Reference | — | — | |
| Current | 1.61 (0.60, 4.14) | — | — | |
| In the past | 2.19 (0.92, 5.20) | — | — | |
| PAD | 0.46 (0.02, 2.96) | 0.53 | — | — |
| LVEF (+5% increase) | 0.88 (0.73, 1.06) | 0.17 | — | — |
| LDL (+1 mmol/l) | 0.94 (0.68, 1.26) | 0.69 | — | — |
| ACEI or ARB use | 0.60 (0.21, 1.87) | 0.36 | — | — |
| Beta-blockers use | 2.28 (0.81, 8.20) | 0.13 | — | — |
| Vessel tested | 0.75 | — | — | |
| LAD | Reference | — | — | |
| LCx | 0.94 (0.40, 2.13) | — | — | |
| RCA | 0.68(0.23, 1.80) | — | — | |
| RFR (0.05 lower) | 1.30 (1.01, 1.67) | 0.049 | 1.22 (0.94, 1.61)### | 0.130 |
| FFR (0.05 lower) | 0.93 (0.75,1.14) | 0.44 | NA | |
| CFR (1 unit decrease) | 1.66 (1,13, 2.56) | 0.007 | 1.69 (1.15, 2.70)### | 0.016 |
| IMR_calc_Yong (1 unit increase) | 1.02 (0.99, 1.04) | 0.17 | ||
| RRR (1 unit decrease) | 1.35 (1.04, 1.85) | 0.38 | 1.37 (1.04, 1.89)### | 0.024 |
| CMD confirmed | 2.55 (1.25, 5.33) | 0.010 | 2.40 (1.15, 5.14)### | 0.019 |
—Not applicable;
#
adjusted for sex only;
##
adjusted for age only;
###
adjusted for sex and age; ACEI, angiotensin; ARB, angiotensin receptor blockers; BMI, body mass index; CFR- coronary flow reserve; DHP dihydropyridine, CMD, coronary microcirculatory dysfunction; FFR, fractional flow reserve; LAD, left anterior descending, LCx, left circumflex; LDL, low-density lipoprotein; LVEF, left ventricle ejection fraction; PAD, peripheral artery disease; RCA, right coronary artery; RFR, resting full-cycle ratio; RRR, relative reserve ratio.