TABLE 4.
Summary of subgroup analysis on brain water content.
| Pooled estimates | No. of studies | Std. MD (95% CI) | p value | Group p-value |
|---|---|---|---|---|
| Model | <0.00001 | |||
| MCAO | 8 | −5.51 [−6.21, −4.80] | p < 0.00001 | |
| BCCAO | 1 | −16.41 [−17.67, −15.15] | p < 0.00001 | |
| Species | ||||
| SD rats | 9 | −8.10 [−8.71, −7.48] | p < 0.00001 | |
| Route of administration | <0.00001 | |||
| i.p | 7 | −7.84 [−8.49, −7.20] | p < 0.00001 | |
| i.v | 1 | −17.46 [−21.30, −13.62] | p < 0.00001 | |
| ICA | 1 | −7.98 [−10.50, −5.46] | p < 0.00001 | |
| Dosage | <0.00001 | |||
| <20 mg/kg | 3 | −4.90 [−6.08, −3.71] | p < 0.00001 | |
| 20 mg/kg | 2 | −9.83 [−10.70, −8.97] | p < 0.00001 | |
| 30 mg/kg | 2 | −4.38 [−5.80, −2.96] | p < 0.00001 | |
| >30 mg/kg | 3 | −7.22 [−8.64, −5.81] | p < 0.00001 | |
| Administration time | <0.00001 | |||
| Before I/R | 3 | −10.09 [−10.95, −9.22] | p < 0.00001 | |
| After I/R | 5 | −8.49 [−9.80, −7.19] | p < 0.00001 | |
| Before and after I/R | 1 | −4.04 [−5.22, −2.86] | p < 0.00001 | |
| Occlusion time | <0.00001 | |||
| 60 min | 1 | −5.34 [−7.36, −3.33] | p < 0.00001 | |
| 90 min | 2 | −5.21 [−6.34, −4.08] | p < 0.00001 | |
| 120 min | 6 | −9.92 [−10.71, −9.13] | p < 0.00001 |
BCCAO, the bilateral common carotid arteries occlusion; MCAO, middle cerebral artery occlusion; ICA, intra-carotid artery; I/R, ischemia/reperfusion; i.g., intragastric gavage; i.p., intraperitoneal; i.v., intravenous injection; SD, Sprague-Dawley.