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. 2022 Oct 5;13:1012294. doi: 10.3389/fphar.2022.1012294

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Copyright © 2022 Qu, Deng, Li, Li, Liu, Wang, Liu, Yu, Cheng, Zhou, Chen, Ren, Yu, Su, Zhao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioequivalence analysis of Cefaclor granule and Cefaclor suspension. The bioequivalence analysis of Cefaclor granule and Cefaclor suspension during fasting (A) shows the ratio range of the main PK parameters of Cefaclor granule and Cefaclor suspension with 90% CI. The bioequivalence analysis of Cefaclor granule and Cefaclor suspension in postprandial state (B) shows the ratio range of the main PK parameters with 90% CI (bioequivalence was declared if the 90% CIs were within the prespecified acceptable ranges of 80–125%). AUC0-t: AUC of the analyte in the plasma over the time interval from time zero to the last measurable concentration; AUC0-∞: AUC of the analyte in the plasma over the time interval from time zero to infinity; Cmax: maximum observed drug concentration in the plasma.