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. 2022 Oct 5;13:1007274. doi: 10.3389/fphar.2022.1007274

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Copyright © 2022 He, Yang, Zhang, Li, Li, Pu, He, Zhang, Yang, Yu, Qi, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of EPC on bile acid profiles in serum and feces. (A) BAs concentration in serum. (B) BAs concentration in feces. (C) Serum and fecal primary BAs concentration/serum and fecal TBAs concentration box chart. (D) Serum and fecal secondary BAs concentration/serum and fecal BAs concentration box chart. (E) Serum and fecal concentrations of conjugated BAs/serum and fecal TBAs concentrations box chart. (F) Free BAs concentration in serum and feces/serum and fecal BAs concentration box chart. n = 3, data are presented as mean ± SEM. CA, 12-keto-CDCA, HDCA, MDCA, and TCA in serum and GDCA, MDCA, HDCA, TDCA in feces by Tukey’s post hoc test. The rest of the data were tested using paired Student‘s t-tests. *p < 0.05, **p < 0.01, ***p < 0.001 vs MOD group. CA, cholic acid; GCDCA, glycine (G)-chenodeoxycholic acid; GDCA, G-deoxycholic acid; MDCA, murideoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, taurine (T)-UDCA; HCA, hyocholic acid; HDCA, hyodeoxycholic acid.