FIGURE 9.

Proposed mechanism for P. cocos on MAFLD. Poria cocos activation of hepatic FXR, which can activate PPARα, inhibit SREBP-1c, reduces lipid deposits. Activation of hepatic FXR, which can activate SHP, inhibit SREBP-1c, reduce TC, TG, NEFA levels and inhibit lipid synthesis. Activation of hepatic FXR, which can activate SHP, reduce CYP7A1 expression and inhibit BA synthesis and lipid absorption; In addition, decreased free bile acids and increased bound bile acids in the intestine can inhibit FXR expression, promote FGF15/19 expression, and reduced bile acid absorption by binding to FGFR4 and inhibiting CYP7A1 expression. FGF15/19, fibroblast growth factor FGF15/19. FGFR4, fibroblast growth factor receptor 4.