TABLE 1.
Tabular record of in-silico method analysis result to predict the impact of SNVs over structure and functions.
| S. no. | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| mutTCPdb ID | tcp8461 | tcp8462 | tcp8463 | tcp8464 |
| Mutation | P163R | I427S | D433H | V477A |
| Sift | Deleterious (0) | Deleterious (0) | Deleterious (0.01) | Deleterious (0) |
| PolyPhen | Possibly damaging (0.906) | Probably damaging (0.996) | Possibly damaging (0.897) | Possibly damaging (0.554) |
| CADD PHRED | 26 | 27.7 | 27 | 26 |
| PROVEAN | Deleterious (−8.537) | Deleterious (−4.878) | Deleterious (−3.258) | Deleterious (−3.377) |
| PON-P2 | Pathogenic (−0.883) | Pathogenic (−0.883) | Pathogenic (−0.819) | Unknown (−0.65) |
| PANTHER | Probably_ damaging (0.57) | Probably_ damaging (0.57) | Probably_ damaging (0.57) | Probably_ damaging (0.57) |
| I-Mutant (DDG kcal/mol) | Decrease (−1.30) | Decrease (−2.44) | Decrease (−0.32) | Decrease (−1.70) |
| DUET (DDG kcal/mol) | Destabilising (−1.668) | Destabilising (−3.704) | Destabilising (−0.637) | Destabilising (−2.1) |
| CUPSAT (DDG kcal/mol) | Destabilising (−3.37) | Destabilising (−7.85) | Destabilising (−1.63) | Destabilising (−5.05) |
| REVEL (expected accuracy) | Pathogenic (−0.958) | Pathogenic (−0.938) | Pathogenic (−0.736) | Pathogenic (−0.908) |
| PredictSNP (expected accuracy) | Deleterious (−0.869) | Deleterious (−0.655) | Neutral (−0.752) | Deleterious (−0.506) |
| MAPP (expected accuracy) | Deleterious (−0.783) | Deleterious (−0.589) | Neutral (−0.653) | Deleterious (−0.588) |
| PhD-SNP (expected accuracy) | Deleterious (−0.875) | Deleterious (−0.589) | Deleterious (−0.589) | Deleterious (−0.676) |