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. 2022 Oct 5;13:986931. doi: 10.3389/fphar.2022.986931

FIGURE 4.

FIGURE 4

MLF and MLP treatment improved metabolic parameters of glucose tolerance and insulin resistance, and alleviated hepatic steatosis in ob/ob mice. (A) Experimental scheme of the ob/ob mouse protocol. (B) OGTT (oral glucose tolerance tests) and (C) AUC of the OGTT on the 13th week of treatment in ob/ob mice. (D) ITT (insulin tolerance tests) and (E) AUC of the ITT on the 14th week of treatment in ob/ob mice. (F) Fasting blood glucose in serum. (G) Serum insulin levels. (H) HOMA-IR index. (I) HOMA-ISI index. (J) Representative pictures of liver stained with H&E (magnification: ×40). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, compared with WT group; # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001, compared with the ob/ob group.