TABLE 4.
Annotation of KEGG pathways of mulberry (Morus alba L.) leaf flavonoids and Ramulus Mori alkaloids.
| Term ID | Description | Count | p Value | Genes |
|---|---|---|---|---|
| hsa05200 | Pathways in cancer | 52 | 9.87066E-56 | AGTR1, AKT1, ALK, AR, BRAF, CASP3, CASP8, CDK2, CDK6, CSF1R, CTNNB1, EDNRB, EGFR, ERBB2, ESR1, ESR2, F2, FLT3, GSK3B, HDAC1, HDAC2, HSP90AA1, IGF1R, IL2, JAK1, JAK2, JAK3, KIT, MDM2, MET, MMP1, MMP2, MMP9, NFKB1, NOS2, NTRK1, PDGFRA, PGF, PIK3R1, PPARG, PRKCA, PRKCB, PRKCG, MAPK1, MAP2K1, PTGS2, RELA, RXRA, STAT3, TERT, VEGFA, WNT3A |
| hsa04920 | Adipocytokine signaling pathway | 7 | 2.6053E-08 | AKT1, JAK2, NFKB1, PPARA, RELA, RXRA, STAT3 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 20 | 4.93654E-30 | AKT1, BRAF, EGFR, ERBB2, GSK3B, IGF1R, JAK1, JAK2, KDR, MET, PDGFRA, PIK3R1, PRKCA, PRKCB, PRKCG, MAPK1, MAP2K1, SRC, STAT3, VEGFA |
| hsa04932 | Non-alcoholic fatty liver disease | 12 | 5.81113E-12 | AKT1, CASP3, CASP8, GSK3B, INSR, NFKB1, PIK3R1, PPARA, PPARG, RELA, RXRA, EIF2AK3 |
| hsa05216 | Thyroid cancer | 7 | 2.7995E-10 | BRAF, CTNNB1, NTRK1, PPARG, MAPK1, MAP2K1, RXRA |
| hsa04910 | Insulin signaling pathway | 10 | 6.41988E-10 | AKT1, BRAF, FASN, GSK3B, INSR, PDPK1, PIK3R1, MAPK1, MAP2K1, PTPN1 |
| hsa05417 | Lipid and atherosclerosis | 23 | 3.16371E-25 | AKT1, CASP1, CASP3, CASP8, CYP1A1, GSK3B, HSP90AA1, JAK2, MMP1, MMP3, MMP9, NFKB1, PDPK1, PIK3R1, PPARG, PRKCA, MAPK1, RELA, RXRA, SELP, SRC, STAT3, EIF2AK3 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 17 | 1.93973E-22 | AGTR1, AKT1, CASP3, F3, JAK2, MMP2, NFKB1, PIK3R1, PRKCA, PRKCB, PRKCD, PRKCE, MAPK1, RELA, STAT3, VEGFA, NOX4 |
| hsa04931 | Insulin resistance | 13 | 2.25338E-15 | AKT1, GSK3B, INSR, NFKB1, PDPK1, PIK3R1, PPARA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, STAT3 |
| hsa04520 | Adherens junction | 10 | 8.29E-13 | ACP1, CTNNB1, EGFR, ERBB2, IGF1R, INSR, MET, MAPK1, PTPN1, SRC |
| hsa04913 | Ovarian steroidogenesis | 6 | 1.08695E-07 | CYP1A1, CYP1B1, CYP19A1, IGF1R, INSR, PTGS2 |
| hsa04151 | PI3K-Akt signaling pathway | 32 | 1.3511E-32 | AKT1, CDK2, CDK6, CSF1R, EGFR, ERBB2, FLT3, GSK3B, HSP90AA1, IGF1R, IL2, INSR, JAK1, JAK2, JAK3, KDR, KIT, MDM2, MET, NFKB1, NTRK1, PDGFRA, PDPK1, PGF, PIK3CG, PIK3R1, PRKCA, MAPK1, MAP2K1, RELA, RXRA, VEGFA |
| hsa04072 | Phospholipase D signaling pathway | 15 | 2.02471E-16 | AGTR1, AKT1, AVPR2, EGFR, F2, CXCR1, CXCR2, INSR, KIT, PDGFRA, PIK3CG, PIK3R1, PRKCA, MAPK1, MAP2K1 |
| hsa04916 | Melanogenesis | 11 | 1.05866E-12 | CTNNB1, EDNRB, GSK3B, KIT, PRKCA, PRKCB, PRKCG, MAPK1, MAP2K1, TYR, WNT3A |
| hsa05222 | Small cell lung cancer | 10 | 1.19614E-11 | AKT1, CASP3, CDK2, CDK6, NFKB1, NOS2, PIK3R1, PTGS2, RELA, RXRA |
| hsa04152 | AMPK signaling pathway | 10 | 1.73256E-10 | AKT1, CFTR, FASN, HMGCR, IGF1R, INSR, PDPK1, PIK3R1, PPARG, SIRT1 |
| hsa04930 | Type II diabetes mellitus | 6 | 5.75767E-08 | CACNA1C, INSR, PIK3R1, PRKCD, PRKCE, MAPK1 |
| hsa04923 | Regulation of lipolysis in adipocytes | 6 | 1.92408E-07 | ADORA1, AKT1, INSR, PIK3R1, PTGS1, PTGS2 |
| hsa00910 | Nitrogen metabolism | 4 | 8.67479E-07 | CA1, CA2, CA3, CA4 |
| hsa00052 | Galactose metabolism | 6 | 2.08301E-15 | GAA, GANC, GLA, GLB1, SI, MGAM |
| hsa00500 | Starch and sucrose metabolism | 5 | 3.57233E-12 | AGL, GAA, GANC, SI, MGAM |
| hsa00511 | Other glycan degradation | 5 | 8.15532E-14 | FUCA1, GBA, GLB1, MAN2B1, GBA2 |
| hsa04142 | Lysosome | 6 | 1.81021E-11 | FUCA1, GAA, GBA, GLA, GLB1, MAN2B1 |
| hsa00600 | Sphingolipid metabolism | 4 | 6.03913E-09 | GBA, GLA, GLB1, GBA2 |