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. 2022 Oct 4;13:1020902. doi: 10.3389/fimmu.2022.1020902

Figure 1.

Figure 1

MMP-7 is highly expressed in patients with ulcerative colitis (UC) and in rodents with experimental colitis. (A) RT-qPCR analysis of MMP7 mRNA levels in mucosa biopsies from control subjects and patients with UC (n=10). (B) Representative images of immunostaining for MMP-7 in human colon biopsy samples. (C) Quantification of MMP-7 staining intensity, ranging from absent (0) to highest (3). RT-qPCR also showed up-regulation of Mmp7 mRNA expression in the colons of DSS rats (D), TNBS rats (E), DSS mice (F), TNBS mice (G), IL10-/- mice (H), and T-cell transfer colitis mice (I). n=4 or 5. *p<0.01. (J) Immunofluorescence staining of MMP-7 in the colons of control (Ctl) and DSS rats. (K) MMP-7 protein staining intensity in control and DSS rats. (L) Representative images of MMP-7 staining of the colons from WT and Il10 -/- mice. (M) Quantification of MMP-7 staining intensity in the colons of WT and Il10 -/- mice.