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. 2022 Oct 4;13:1020902. doi: 10.3389/fimmu.2022.1020902

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Copyright © 2022 Xiao, Lian, Zhong, Krishnachaitanya, Cong, Dashwood, Savidge, Powell, Liu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MMP-7 deficiency ameliorates DSS-induced colitis. Colitis was induced with 3% DSS in drinking water in C57BL/6 (A) and Mmp7 ^-/- (B) mice for 7 days. (C) Body weight. (D) Colon length. Colon tissue was collected for detection of myeloperoxidase (MPO) activity (E) and mRNA levels of inflammation-related genes. Messenger RNA (mRNA) levels of Il6 (F), Il1b (G), Tnfa (H), Il18 (I), Nlrp3 (J), Mmp3 (K), and Mmp9 (L) were quantified by RT-qPCR. Serum levels of IL-6 (M) and IL-1β (N) were assessed by ELISA. (O) Histologic staining (H, E) of the colons. Green arrow, inflammatory infiltrate. Red arrow, distorted crypt. (P) Histological colitis score of the colons. n=4 or 5. *p<0.05 vs wild type control. **p<0.05 vs wild type mice with DSS. NS, not significant.