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. 2022 Oct 5;10:998373. doi: 10.3389/fcell.2022.998373

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Copyright © 2022 Lessey, Robinson, Chaudhary and Daniel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of cell-cell adhesion complexes in intestinal epithelial cells. The tight junction (TJ) is the most apical cell adhesion complex and functions to establish polarity and regulate paracellular permeability. Immediately basal to the TJ is the adherens junction (AJ), which plays a key role in mediating cell-cell adhesion. Desmosomal complexes are basal to AJ and are key for strengthening cell-cell adhesion and withstanding mechanical stress. The proteins emphasized in this review are bolded.