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. 2022 Oct 5;10:998373. doi: 10.3389/fcell.2022.998373

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Copyright © 2022 Lessey, Robinson, Chaudhary and Daniel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adherens junction (AJ) protein interactions in the nucleus. Many AJ proteins interact with components of the canonical Wnt signaling pathway. (1). β-catenin interacts directly with TCF/LEF to activate Wnt target genes. (2). α-catenin, γ-catenin and α-catenin/APC complexes interact with the β-catenin-TCF/LEF heterodimer and prevents its association with DNA, thereby inhibiting expression of Wnt target genes. (3). γ-catenin binds directly to TCF/LEF and activates TCF/LEF-dependent gene expression. (4). E-cadherin interacts with β-catenin and disrupts its interaction with TCF/LEF cofactors.