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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Neurosci. 2022 Sep 28;25(10):1366–1378. doi: 10.1038/s41593-022-01166-7

Fig. 7 |. Definition of neuronal and non-neuronal cis-regulatory domains.

Fig. 7 |

a, An example of cis-regulatory domains in STG neurons identified by estimating the interindividual correlation structure between nearby OCRs. From top to bottom: genes that are present in the locus; a single Hi-C TAD (dark gray horizontal bar) and Hi-C loops (red arcs); OCRs (gray vertical bars); CRDs, where each colorbar represents a different regulatory domain; correlation matrix of OCRs including colored triangles that highlight CRDs. b, Number of CRDs stratified by cell type and brain region. The percentage is the fraction of OCRs within CRDs to the total number of OCRs. c, Venn diagrams by cell type and brain region summarizing the overlap of CRDs. “J” indicates the Jaccard index between the respective CRDs. d, CTCF density at and around CRD and TAD boundaries. e, Size distribution of cell type and region specific CRDs and cell type specific TADs. f, Associations of enhancer-promoter regions (ABC method) that are within the same CRDs. The odds ratios with their 95% confidence intervals are plotted as a function of the distance between enhancer and gene TSSs. P-values are estimated based on a two-sided Fisher’s exact test. CRD: cis-regulatory domain; TAD: topologically associating domain; kb: kilobase; and Mb: megabase.