Figure 4.

Interaction network among 143 high-confidence genes

Network is built using STRING edges. Nodes are colored based on their differential log2 fold change expression in AD brains. Red rings around genes indicate that they were reported in MGI to have abnormal neurological phenotype when knocked out. Green rings indicate that the gene was observed to modify AD phenotype in in vivo experiments on AD Drosophila models. Yellow rings indicate genes that were observed to both modify AD phenotype in Drosophila models and have reported abnormal neurological phenotype in knockout (KO) mouse models in MGI. Genes with asterisk next to them are those that have pre-existing FDA-approved pharmacological activator or inhibitors, indicating potential targets for drug-repurposing studies.