Figure 4.

Pink1 KO neurons exhibit significantly reduced frequency of mEPSCs compared with WT neurons. A, Representative traces illustrating mEPSCs recorded at −70 mV in WT or Pink1 KO primary neuronal cultures (left) and averaged mEPSCs (right). B–D, Amplitude (B), frequency (C), and decay time constant (D; τ) of the mEPSCs recorded from WT and Pink1 KO neuronal cultures (n = 5 neurons per genotype; ***p = 0.0001; t = 6.739 using Student's unpaired t test). E, Representative interevent intervals cumulative probability curve. F, Interevent intervals for mEPSCs compared between WT and Pink1 KO neuronal cultures (n = 5 neurons per genotype; ****p < 0.000001; F = 2638 using F test).