Figure 5.

Postnatal day 21 and adult offspring gene expression (qPCR). A–F, In the mPFC at P21, MO offspring had increased expression of ITGAM (CR3/CD11b; A), MYD88 (B), DLG4 (PSD-95; C), COMT (D), PNOC (E), and DNMT3A (F) (A-F, MO: *p < 0.05 drug main effect, two-way ANOVA). G, In the AMG, MO offspring had reduced SLC17A7 (VGluT1) expression (MO: *p < 0.05 drug main effect, two-way ANOVA). H, In the VTA, male MO had reduced TLR4 expression compares to male SAL (#p < 0.05 drug × sex interaction, *p < 0.05 vs male SAL, two-way ANOVA). I, J, In the adult AMG, male MO offspring had increased expression of IL-1β (I) and NTS (J). *p < 0.05 versus male SAL, t test. Refer to Extended Data Figure 5-1 for effects of sex at P21.