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Renal fibrosis and ferroptosis. Studies have shown that ferroptosis happens during renal fibrosis and that ferroptosis also contributes significantly in the progression of renal fibrosis and promotes fibroblast differentiation. Unfavorable factors (injury, inflammation, toxins, etc.) can crosstalk with renal ferroptosis, resulting in ferroptosis-specific changes. Targeting ferroptosis for renal fibrosis and CKD has great potential.
