Figure 2.

Correlations between GPX4 levels and clinicopathological parameters. (a–f) Kidney tubulointerstitial GPX4 level was significantly correlated with eGFR (a), proteinuria (b), Scr (c), uACR (d), percentage of sclerosed glomeruli (e), and eGFR slope (f). (g, h) Representative photographs (g) and semiquantification (h) of GPX4 IHC staining in DKD patients with different IFTA scores. Scale bar = 50 μm (g). Horizontal lines represent mean ± SD (h). DKD: diabetic kidney disease; eGFR: estimated glomerular filtration rate; IFTA: interstitial fibrosis and tubular atrophy; IOD/area: the staining intensity of GPX4; Scr: serum creatinine; uACR: urinary albumin-to-creatinine ratio. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.