Table 2.
Cox regression analysis for the endpoint in patients with DKD.
| Factors | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age | 1.02 (0.99 to 1.04) | 0.153 | 1.02 (1.00 to 1.05) | 0.089 |
| Sex (female vs. male) | 0.38 (0.18 to 0.82) | 0.013 | 0.41 (0.18 to 0.95) | 0.037 |
| IOD/area (GPX4-low vs. GPX4-high) | 2.47 (1.33 to 4.60) | 0.004 | 2.15 (1.08 to 4.28) | 0.030 |
| eGFR (>60 vs. ≤60 mL/min/1.73 m2) | 0.34 (0.16 to 0.70) | 0.004 | 1.11 (0.40 to 3.13) | 0.841 |
| IFTA (>2 vs. ≤2) | 3.14 (1.74 to 5.69) | <0.001 | 2.75 (1.14 to 6.63) | 0.024 |
| Pathological type (I and II vs. III and IV) | 1.77 (0.83 to 3.78) | 0.142 | 1.43 (0.62 to 3.33) | 0.402 |
| RAAS inhibitors use (yes vs. no) | 0.54 (0.30 to 0.97) | 0.038 | 0.78 (0.41 to 1.49) | 0.452 |
DKD: diabetic kidney disease; eGFR: estimated glomerular filtration rate; IFTA: interstitial fibrosis and tubular atrophy; IOD/area: the staining intensity of GPX4; RAAS: renin-angiotensin-aldosterone system.