Table 4.
Corneal nerve parameters measured with CCM, macular and optic nerve head retinal parameters measured with SD-OCT in different sectorial patterns in study subjects according to MIR128a genotype
| MIR128a Genotypes | |||||
|---|---|---|---|---|---|
| CC (n = 93) | CT (n = 43) | TT (n = 4) | P* | CC versus CT + TT P** | |
| CNFD (n/mm2) | 25.32 (4.40) | 23.68 (5.15) | 20.31 (4.98) | 0.045 | 0.028 |
| CNBD (n/mm2) | 29.30 (10.80) | 25.58 (8.93) | 21.58 (8.05) | 0.135 | 0.025 |
| CNFL (mm/mm2) | 15.44 (2.45) | 14.19 (2.48) | 13.29 (2.74) | 0.033 | 0.004 |
| CTBD (n/mm2) | 44.72 (15.85) | 38.68 (14.29) | 39.45 (11.51) | 0.115 | 0.039 |
| CNFrD | 1.49 (0.02) | 1.48 (0.03) | 1.47 (0.02) | 0.026 | 0.022 |
| TRT (µm) | 298.82 (12.79) | 299.50 (11.77) | 302.83 (7.51) | 0.79 | 0.69 |
| superior TRT (µm) | 299.44 (13.72) | 299.59 (12.28) | 304.33 (6.81) | 0.67 | 0.84 |
| inferior TRT (µm) | 298.76 (13.46) | 299.29 (11.73) | 301.67 (8.81) | 0.92 | 0.77 |
| GCL (µm) | 33.51 (2.52) | 33.81 (2.52) | 34.00 (1.08) | 0.71 | 0.51 |
| superior GCL (µm) | 33.48 (2.57) | 33.85 (2.76) | 34.13 (1.44) | 0.68 | 0.42 |
| inferior GCL (µm) | 33.60 (2.58) | 33.84 (2.47) | 34.38 (1.11) | 0.66 | 0.54 |
| global MRW (µm) | 373.95 (56.55) | 343.83 (49.24) | 355.88 (36.54) | 0.02 | 0.006 |
| temporal MRW (µm) | 271.77 (50.29) | 256.81 (41.15) | 243.63 (31.32) | 0.23 | 0.045 |
| temporal superior MRW (µm) | 355.01 (62.97) | 329.73 (46.87) | 357.88 (61.65) | 0.17 | 0.032 |
| temporal inferior MRW (µm) | 399.99 (65.50) | 375.27 (54.60) | 361.00 (44.59) | 0.10 | 0.020 |
| nasal MRW (µm) | 410.72 (65.68) | 370.03 (62.11) | 397.25 (40.34) | 0.02 | 0.003 |
| nasal superior MRW (µm) | 414.22 (78.17) | 378.07 (62.43) | 429.75 (99.80) | 0.06 | 0.035 |
| nasal inferior MRW (µm) | 456.77 (78.00) | 416.46 (72.56) | 414.63 (68.85) | 0.03 | 0.007 |
| global RNFL (µm) | 102.94 (9.80) | 102.47 (8.21) | 102.38 (12.17) | 0.97 | 0.780 |
| temporal RNFL (µm) | 72.45 (9.39) | 74.33 (8.85) | 68.50 (6.28) | 0.39 | 0.461 |
| temporal superior RNFL (µm) | 135.48 (18.66) | 135.03 (18.90) | 129.00 (20.40) | 0.66 | 0.768 |
| temporal inferior RNFL (µm) | 154.33 (16.88) | 158.23 (15.92) | 141.38 (21.46) | 0.13 | 0.510 |
| nasal RNFL (µm) | 84.99 (12.74) | 84.67 (10.61) | 83.63 (8.27) | 0.98 | 0.850 |
| nasal superior RNFL (µm) | 118.54 (21.17) | 113.36 (18.20) | 126.00 (34.04) | 0.52 | 0.33 |
| nasal inferior RNFL (µm) | 120.55 (23.81) | 117.60 (22.66) | 141.75 (29.61) | 0.39 | 0.92 |
CNFL Corneal Nerve Fiber Length, CNFD Corneal Nerve Fiber Density, CNBD Corneal Nerve Branch Density, CTBD corneal Nerve Fiber Total Branch Density, CNFrD Corneal Nerve Fiber Fractal Dimension, TRT total retinal thickness, GCL ganglion cell layer thickness, MRW minimum rim width, RNFL retinal nerve fiber layer
Genotype–phenotype association analysis was performed using Kruskall–Wallis test* and t-test**
Bold values indicate p values < 0.05