Table 5.

Multiple regression analysis of MIR146a genotype, clinical and biochemical parameters for the risk factors for diabetes complications measured at IVCM and OCT evaluation

Dependent variable	Variables in the model	B	95% CI	P
CNFL (model R2 = 0.118, p = 0.040)	Age	0.105	− 0.088–0.299	0.283
	Diabetes duration	− 0.89	− 0.219–0.041	0.176
	HbA1c	− 0.534	− 1.254–0.185	0.144
	SBP percentile	− 0.002	− 0.021–0.016	0.790
	MIR146a genotypes*	1.014	0.066–1.963	0.036
CNFD (model R2 = 0.118, p = 0.041)	Age	0.163	− 0.240–0.565	0.425
	Diabetes duration	− 0.235	− 0.504–0.035	0.087
	HbA1c	− 1.090	− 2.585–0.405	0.151
	SBP percentile	0.013	− 0.025–0.051	0.486
	MIR146a genotypes*	2.029	0.057–4.00	0.044
CNBD (model R2 = 0.183, p = 0.002)	Age	0.855	0.33–1.677	0.042
	Diabetes duration	− 0.724	− 1.274– − 0.174	0.011
	HbA1c	− 2.823	− 5.873–0.227	0.069
	SBP percentile	− 0.050	− 0.127–0.027	0.201
	MIR146a genotypes*	3.795	− 0.228–7.818	0.064
CTBD (model R2 = 0.146, p = 0.012) CNFFrD (model R2 = 0.165, p = 0.005)	Age	1.287	0.100–2.574	0.040
	Diabetes duration	− 0.834	− 1.695–0.027	0.058
	HbA1c	− 3.622	− 8.396–1.151	0.135
	SBP percentile	− 0.101	− 0.222–0.020	0.101
	MIR146a genotypes*	− 4.528	− 1.768–10.823	0.157
	Age	0.001	0.00–0.003	0.139
	Diabetes duration	− 0.001	− 0.002–0.000	0.143
	HbA1c	− 0.005	− 0.12–0.001	0.111
	SBP percentile	0.0	0.0	0.933
	MIR146a genotypes*	0.12	0.003–0.021	0.007
global MRW (model R2 = 0.128, p = 0.013)	Age	1.847	− 2.918–6.612	0.444
	Diabetes duration	− 2.099	− 5.371–1.174	0.206
	HbA1c	− 17.311	− 34.177– − 0.446	0.044
	SBP percentile	0.266	− 0.176–0.707	0.236
	MIR146a genotypes*	26.002	2.104– − 49.899	0.033

CNFL Corneal Nerve Fiber Length, CNFD Corneal Nerve Fiber Density, CNBD Corneal Nerve Branch Density, CTBD corneal Nerve Fiber Total Branch Density, CNFrD Corneal Nerve Fiber Fractal Dimension, MRW minimum rim width

^*MIR146A genotypes were codified according to a dominant model for the minor allele C: CC + GC = 1 and GG = 0