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. 2021 Oct 12;24(5):700–709. doi: 10.1007/s11307-021-01655-4

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© The Author(s) 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2. — In vivo MRI and [¹⁸F]FDG PET in tMCAO mouse brain. a Representative PET images of coronal, sagittal and horizontal mouse brain sections after intravenous injection of [¹⁸F]FDG in sham-operated and tMCAO mice. The radiosignals were averaged from 21 to 61 min; b [¹⁸F]FDG accumulation (SUV) at different mouse brain regions (Str: striatum; Ctx: cortex; Cb: cerebellum) in sham and tMCAO mice. Significantly reduced [¹⁸F]FDG accumulation was observed in the ipsilateral striatum compared to contralateral side in tMCAO mice; c–e in vivo T₂-weighted image, ADC map, and ex vivo TTC stained brain sections, indicating the delineation in tMCAO mice. TTC, 2,3,5-triphenyltetrazolium chloride; ADC, apparent diffusion coefficient; SUV, standard uptake value. *p < 0.05.