Table 1.
Brain regions | Main effect MIA (p-value) |
PND21 | PND60 | PND90 | |||
---|---|---|---|---|---|---|---|
Control | MIA | Control | MIA | Control | MIA | ||
Amygdala | 0.015 | 1.02 ± 0.16 | 1.31 ± 0.12*** | 2.19 ± 0.19 | 2.45 ± 0.49 | 2.17 ± 0.53 | 2.61 ± 0.44 |
BNST | 0.001 | 1.31 ± 0.26 | 1.75 ± 0.31** | 2.49 ± 0.25 | 2.98 ± 0.62 | 2.51 ± 0.62 | 3.08 ± 0.57 |
Cerebellum | 0.026 | 1.01 ± 0.18 | 1.40 ± 0.13*** | 2.31 ± 0.15 | 2.55 ± 0.41 | 2.31 ± 0.54 | 2.59 ± 0.39 |
Corpus callosum | 0.038 | 1.42 ± 0.32 | 1.77 ± 0.40 | 2.97 ± 0.28 | 3.33 ± 0.67 | 3.01 ± 0.77 | 3.45 ± 0.66 |
Entorhinal cortex | 0.052 | 1.03 ± 0.17 | 1.22 ± 0.25 | 2.37 ± 0.21 | 2.68 ± 0.50 | 2.42 ± 0.59 | 2.81 ± 0.51 |
Frontal association cortex | 0.001 | 1.01 ± 0.15 | 1.15 ± 0.33 | 1.9 ± 0.12 | 2.47 ± 0.39** | 2.07 ± 0.30 | 2.50 ± 0.47* |
Insular cortex | 0.013 | 1.19 ± 0.20 | 1.50 ± 0.10 | 2.61 ± 0.25 | 3.01 ± 0.53 | 2.84 ± 0.63 | 3.41 ± 0.73 |
Medial prefrontal cortex | 0.027 | 1.39 ± 0.30 | 1.82 ± 0.41* | 3.03 ± 0.37 | 3.55 ± 0.71 | 3.19 ± 0.80 | 3.67 ± 0.78 |
Orbitofrontal | 0.011 | 1.42 ± 0.29 | 1.76 ± 0.41 | 2.94 ± 0.29 | 3.55 ± 0.61 | 3.22 ± 0.72 | 3.74 ± 0.75 |
Occipital cortex | 0.201 | 1.07 ± 0.22 | 1.24 ± 0.26 | 2.31 ± 0.18 | 2.47 ± 0.44 | 2.30 ± 0.57 | 2.53 ± 0.49 |
Nucleus accumbens | 0.014 | 1.29 ± 0.23 | 1.64 ± 0.37 | 2.87 ± 0.29 | 3.28 ± 0.65 | 2.90 ± 0.76 | 3.46 ± 0.68 |
Striatum | 0.011 | 1.43 ± 0.30 | 1.82 ± 0.42 | 2.87 ± 0.26 | 3.44 ± 0.70 | 3.04 ± 0.79 | 3.62 ± 0.71 |
Hippocampus | 0.010 | 1.31 ± 0.29 | 1.59 ± 0.37 | 2.66 ± 0.25 | 3.07 ± 0.61 | 2.63 ± 0.64 | 3.17 ± 0.57 |
Whole brain | 0.017 | 1.19 ± 0.23 | 1.51 ± 0.24* | 2.51 ± 0.21 | 2.84 ± 0.51 | 2.56 ± 0.61 | 2.98 ± 0.54 |
Temporal cortex | 0.028 | 1.12 ± 0.20 | 1.36 ± 0.27 | 2.45 ± 0.21 | 2.81 ± 0.49 | 2.60 ± 0.61 | 3.04 ± 0.58 |
Frontal cortex | 0.010 | 1.12 ± 0.20 | 1.39 ± 0.27* | 2.36 ± 0.20 | 2.7 ± 0.45* | 2.44 ± 0.52 | 2.84 ± 0.54 |
Parietal cortex | 0.044 | 1.14 ± 0.23 | 1.43 ± 0.30 | 2.46 ± 0.22 | 2.68 ± 0.44 | 2.53 ± 0.59 | 2.86 ± 0.54 |
thalamus | 0.002 | 1.25 ± 0.26 | 1.63 ± 0.36* | 2.50 ± 0.23 | 2.94 ± 0.59 | 2.57 ± 0.63 | 3.1 ± 0.55 |
midbrain | 0.006 | 1.45 ± 0.33 | 1.81 ± 0.41 | 2.72 ± 0.26 | 3.07 ± 0.63 | 2.7 ± 0.64 | 3.2 ± 0.58 |
Brainstem | 0.020 | 1.28 ± 0.28 | 1.64 ± 0.20* | 2.54 ± 0.23 | 2.82 ± 0.53 | 2.52 ± 0.59 | 2.92 ± 0.46 |
Basal ganglia | 0.003 | 1.25 ± 0.23 | 1.60 ± 0.31* | 2.47 ± 0.20 | 2.93 ± 0.60 | 2.53 ± 0.65 | 3.07 ± 0.61 |
forebrain | 0.002 | 1.26 ± 0.26 | 1.63 ± 0.35* | 2.49 ± 0.22 | 2.93 ± 0.59 | 2.54 ± 0.63 | 3.08 ± 0.55 |