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. 2022 Apr 5;24(5):740–749. doi: 10.1007/s11307-022-01723-3

Table 1.

[18F]-FDG PET: tracer uptake in the brain of control animals (control), and animals from mothers exposed to poly-I:C injection (MIA). Tracer uptake (SUV) is presented for different brain areas. Data are shown as mean ± SD. Statistically significant differences between MIA and control animals on the same day are indicated in bold and with an asterisk: *p < 0.05; **p < 0.01, ***p < 0.01

Brain regions Main effect MIA
(p-value)
PND21 PND60 PND90
Control MIA Control MIA Control MIA
Amygdala 0.015 1.02 ± 0.16 1.31 ± 0.12*** 2.19 ± 0.19 2.45 ± 0.49 2.17 ± 0.53 2.61 ± 0.44
BNST 0.001 1.31 ± 0.26 1.75 ± 0.31** 2.49 ± 0.25 2.98 ± 0.62 2.51 ± 0.62 3.08 ± 0.57
Cerebellum 0.026 1.01 ± 0.18 1.40 ± 0.13*** 2.31 ± 0.15 2.55 ± 0.41 2.31 ± 0.54 2.59 ± 0.39
Corpus callosum 0.038 1.42 ± 0.32 1.77 ± 0.40 2.97 ± 0.28 3.33 ± 0.67 3.01 ± 0.77 3.45 ± 0.66
Entorhinal cortex 0.052 1.03 ± 0.17 1.22 ± 0.25 2.37 ± 0.21 2.68 ± 0.50 2.42 ± 0.59 2.81 ± 0.51
Frontal association cortex 0.001 1.01 ± 0.15 1.15 ± 0.33 1.9 ± 0.12 2.47 ± 0.39** 2.07 ± 0.30 2.50 ± 0.47*
Insular cortex 0.013 1.19 ± 0.20 1.50 ± 0.10 2.61 ± 0.25 3.01 ± 0.53 2.84 ± 0.63 3.41 ± 0.73
Medial prefrontal cortex 0.027 1.39 ± 0.30 1.82 ± 0.41* 3.03 ± 0.37 3.55 ± 0.71 3.19 ± 0.80 3.67 ± 0.78
Orbitofrontal 0.011 1.42 ± 0.29 1.76 ± 0.41 2.94 ± 0.29 3.55 ± 0.61 3.22 ± 0.72 3.74 ± 0.75
Occipital cortex 0.201 1.07 ± 0.22 1.24 ± 0.26 2.31 ± 0.18 2.47 ± 0.44 2.30 ± 0.57 2.53 ± 0.49
Nucleus accumbens 0.014 1.29 ± 0.23 1.64 ± 0.37 2.87 ± 0.29 3.28 ± 0.65 2.90 ± 0.76 3.46 ± 0.68
Striatum 0.011 1.43 ± 0.30 1.82 ± 0.42 2.87 ± 0.26 3.44 ± 0.70 3.04 ± 0.79 3.62 ± 0.71
Hippocampus 0.010 1.31 ± 0.29 1.59 ± 0.37 2.66 ± 0.25 3.07 ± 0.61 2.63 ± 0.64 3.17 ± 0.57
Whole brain 0.017 1.19 ± 0.23 1.51 ± 0.24* 2.51 ± 0.21 2.84 ± 0.51 2.56 ± 0.61 2.98 ± 0.54
Temporal cortex 0.028 1.12 ± 0.20 1.36 ± 0.27 2.45 ± 0.21 2.81 ± 0.49 2.60 ± 0.61 3.04 ± 0.58
Frontal cortex 0.010 1.12 ± 0.20 1.39 ± 0.27* 2.36 ± 0.20 2.7 ± 0.45* 2.44 ± 0.52 2.84 ± 0.54
Parietal cortex 0.044 1.14 ± 0.23 1.43 ± 0.30 2.46 ± 0.22 2.68 ± 0.44 2.53 ± 0.59 2.86 ± 0.54
thalamus 0.002 1.25 ± 0.26 1.63 ± 0.36* 2.50 ± 0.23 2.94 ± 0.59 2.57 ± 0.63 3.1 ± 0.55
midbrain 0.006 1.45 ± 0.33 1.81 ± 0.41 2.72 ± 0.26 3.07 ± 0.63 2.7 ± 0.64 3.2 ± 0.58
Brainstem 0.020 1.28 ± 0.28 1.64 ± 0.20* 2.54 ± 0.23 2.82 ± 0.53 2.52 ± 0.59 2.92 ± 0.46
Basal ganglia 0.003 1.25 ± 0.23 1.60 ± 0.31* 2.47 ± 0.20 2.93 ± 0.60 2.53 ± 0.65 3.07 ± 0.61
forebrain 0.002 1.26 ± 0.26 1.63 ± 0.35* 2.49 ± 0.22 2.93 ± 0.59 2.54 ± 0.63 3.08 ± 0.55